Teicoplanin is a glycopeptide antibiotic derived from Actinoplanes teichomyceticus. It is supplied as a sterile, pyrogen-free ivory-white powder that dissolves in water to form a clear solution. Teicoplanin works by inhibiting bacterial cell wall synthesis, binding specifically to D-alanyl-D-alanine residues in peptidoglycan, thereby disrupting bacterial growth. This mechanism differs from beta-lactam antibiotics.
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Teconin is used for treating infections in both adults and children, including:
It is also prescribed as an alternative oral therapy for diarrhea and colitis caused by Clostridium difficile. For optimal results, Teconin may be combined with other antibacterial agents as needed.
Bacterial infections
Teconin kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Teconin can be administered intravenously (IV) or intramuscularly (IM):
Dosage adjustments are similar to those in adults. Monitoring drug levels in the blood is advised for effective treatment.
100–200 mg orally twice daily for 7–14 days is recommended. For maximum bactericidal activity or in cases where Gram-negative bacteria cannot be excluded (e.g., neutropenic patients with fever), combination therapy with another suitable antibiotic is advised.
Use cautiously in patients with known hypersensitivity to Vancomycin due to potential cross-reactivity.